Endocrine Abstracts

Goal: To study Prevalence of Preterm menopause and its relation to obesity; to study relation of DM and the age of the first menorrhoea among women over 40 years old.Materials and methods: The study was performed on 640 menopause women (with no menorrhoea during the past 12 months) who participated in ‘sugar and lipid’ study of Tehran during 2006 to 2008. With no history of hysterectomy. Preterm menopause was defined as menopause before 48 year...

BackgroundTo examine the secular trends of dietary food groups and diet quality among adults, overall and by sex, education, and occupation status.MethodsThis study was conducted within the framework of the Tehran Lipid and Glucose Study (TLGS). Demographic and anthropometric measurements were gathered using standard questionnaires. In terms of socioeconomic information, participants were divided into two gro...

Previous observational studies suggest that low 25(OH)D concentrations in childhoodmight have deleterious effects on vasculature. The present study addresses this key knowledge gap with the use of a dose-response randomized clinical trial (RCT) aimed to determine the effect ofone-year vitamin D supplementationon carotid intima media thickness (cIMT) in overweight and obese school children. The current study was a single-blind RCT. A total of 378 children and adolescents, 6&#82...

Background: The aim of this study was to investigate the association between the identified patterns of fruits and vegetables and metabolic syndrome incidence, and to investigate whether lifestyle factors (weight change and smoking) and socioeconomic status (education and occupation status) modify the effect of the patterns on metabolic syndrome risk.Methods: We prospectively studied 1915 participants of the Tehran Lipid and Glucose study aged 19–7...

Background: The aim of this study was to investigate whether both weight change and the background intakes of macronutrients modulate the association between dietary branch chain amino acids (BCAAs) and the risk of metabolic syndrome (MetS).Methods: This prospective study was conducted within the framework of the Tehran Lipid and Glucose Study. BCAA intakes were collected using a valid and reliable semi-quantitative food frequency questionnaire. MetS com...

Goal: To study the relation between the obesity of children and their parents, and energy intake.Materials and methods: Of 236 households containing 828 population (356 children age 5–25 years, and the rest their parents) were selected from the subjects of ‘Tehran Lipid and Glucose study’ (2006–2008) for this study. Food intake of the subjects was studied using FFQ. In this study, energy intake ≥75 percentile was regarded as &#1...

Introduction: Leptin is a well-known adipokine which has a critical role in the regulation of body weight, body fat mass, appetite, and food intakes. Energy-supplying nutrients such as carbohydrates is a dietary-related factor which has potential effects on plasma leptin levels. The effect of habitual carbohydrates intake on leptin gene expression was limited only in animal studies. The current study aimed to investigate the association of habitual carbohydrate intake with lep...

Introduction: Trials on children and adolescents with excess weight are limited and lack parathyroid hormone (PTH) measures as a surrogate marker of vitaminD status in skeletal health. The present study addresses this key knowledge gap with the use of a dose-response randomized clinical trial (RCT) aimed at determining vitamin D requirement to increase 25(OH)D and suppress PTH concentrations in overweight and obese school children.Methods: The current st...

Background and aim: The 25OHD concentration at which intact parathyroid hormone (iPTH) is maximally suppressed and below which PTH begins to rise (inflection point) has been used to define optimum 25OHD concentration. While it is not known if the lower 25OHD levels in obese children are associated with a PTH increase in the same manner as it is in normal weight children, we aimed to study the relation between circulating PTH and 25OHD levels and to search for a 25OHD threshold...

Background and aim: Apelin, as an adipokine, is encoded by the APLN gene. It is a key regulator in glucose and lipid metabolism and plays an important role in the pathogenesis of insulin resistance and type 2 diabetes. It seems that habitual dietary intake of carbohydrates including quality and quantity by chronic manipulating insulin concentration might have a distinguishing role in the prediction of apelin gene expression in adipose tissue, but there is no evidence in this r...